In 1964, while conducting research for the Karmanos Institute, Dr. Jerome P. Horwitz synthesized a compound that was to become known as zidovudine (AZT) - an antiviral drug used to treat HIV patients; Zidovudine was initially developed as a treatment for cancer. Horwitz was also first to synthesize stavudine (d4T) and zalcitabine (ddC) - two other reverse transcriptase inhibitors used in the treatment of HIV patients. (6.2)